基因写下的,或许只是生命的初稿,而经历仍在字里行间不断批注——压力、营养,乃至童年被拥抱与安抚的方式,都可能借由甲基化,在DNA上留下细微的印记,影响基因何时沉默、何时发声。既然生命始终在被经历续写,又怎会有一种预言,能精准推断一个人的命运?
参考文献:
[1]EKUNDAYO B, BLEICHERT F. Origins of DNA replication[J]. PLOS Genetics, 2019, 15(9): e1008320.
[2]Ferry, G. (2019). The structure of DNA. Nature, 575(7781), 35–36.
[3]BĘBENEK A, ZIUZIA-GRACZYK I. Fidelity of DNA replication—a matter of proofreading[J]. Current Genetics, 2018, 64(5): 985-996.
[4]LIU D, FREDERIKSEN J H, LIBERTI S E, et al. Human DNA polymerase delta double-mutant D316A;E318A interferes with DNA mismatch repair in vitro[J]. Nucleic Acids Research, 2017, 45(16): 9427-9440.
[5]KRIEGER L M, ILIAKIS G. Wenn Stränge reißen – Wege der DNA-Doppelstrangbruch-Reparatur[J]. BIOspektrum, 2017, 23(5): 502-505.
[6]STRAUSS B S. Why Is DNA Double Stranded? The Discovery of DNA Excision Repair Mechanisms[J]. Genetics, 2018, 209(2): 357-366.