淋病的四千年史,是欲望与危险之间的永恒摇摆。我们发明了抗生素,以为找到了平衡点,却催生了更强大的耐药菌。这场博弈没有终点,只有不断调整的、脆弱的平衡...
参考文献:
[1]QUILLIN S J, SEIFERT H S. Neisseria gonorrhoeae host adaptation and pathogenesis[J]. Nature Reviews Microbiology, 2018, 16(4): 226-240.
[2]HILL S A, MASTERS T L, WACHTER J. Gonorrhea – an evolving disease of the new millennium[J]. Microbial Cell, 2016, 3(9): 371-389.
[3]SEMCHENKO E A, CHEN X, THNG C, et al. Gonorrhoea: past, present and future[J]. Microbiology Australia, 2020, 41(4): 205-209.
[4]LENZ J D, DILLARD J P. Pathogenesis of Neisseria gonorrhoeae and the Host Defense in Ascending Infections of Human Fallopian Tube[J]. Frontiers in Immunology, 2018, 9. DOI:10.3389/fimmu.2018.02710.
[5]FROST K M, CHARRON-SMITH S L, COTSONAS T C, et al. Rolling the evolutionary dice: Neisseria commensals as proxies for elucidating the underpinnings of antibiotic resistance mechanisms and evolution in human pathogens[J]. Microbiology Spectrum, 2024, 12(2). DOI:10.1128/spectrum.03507-23.
[6]ESCOBAR A, RODAS P I, ACUÑA-CASTILLO C. Macrophage–Neisseria gonorrhoeae Interactions: A Better Understanding of Pathogen Mechanisms of Immunomodulation[J]. Frontiers in Immunology, 2018, 9. DOI:10.3389/fimmu.2018.03044.
[7]UNEMO M, DEL RIO C, SHAFER W M. Antimicrobial Resistance Expressed byNeisseria gonorrhoeae: A Major Global Public Health Problem in the 21st Century[J]. Microbiology Spectrum, 2016, 4(3). DOI:10.1128/microbiolspec.ei10-0009-2015.
[8]FIFER H, JOHNSON A. The continuing evolution of antibiotic resistance in Neisseria gonorrhoeae: past, present and future threats to effective treatment[J]. Journal of Antimicrobial Chemotherapy, 2025, 80(5): 1213-1219.