1997年,布鲁西纳独享诺贝尔奖,颁奖词称他建立了全新生物范式。但回溯1982年,当他提出“传染性纯蛋白质”假说时,遭遇的是整个学界的嘲讽…
参考文献:
[1]Wang K K W, Yang Z, Chiu A, et al. Examining the Neural and Astroglial Protective Effects of Cellular Prion Protein Expression and Cell Death Protease Inhibition in Mouse Cerebrocortical Mixed Cultures [J]. Molecular Neurobiology, 2015, 53(7): 4821–4832.
[2]Klemm H M J, Welton J M, Masters C L, et al. The Prion Protein Preference of Sporadic Creutzfeldt-Jakob Disease Subtypes [J]. Journal of Biological Chemistry, 2012, 287(43): 36465–36472.
[3]Aguzzi A, Heikenwalder M, Polymenidou M. Insights into prion strains and Neurotoxicity [J]. Nature Reviews Molecular Cell Biology, 2007, 8(7): 552–561.
[4]Brown D R. Prion and prejudice: Normal protein and the Synapse [J]. Trends in Neurosciences, 2001, 24(2): 85–90.