Civil structures and infrastructure provide vital services that support and enable societal functions. However, they are vulnerable to several hazards. To wisely invest the limited funding, it is crucial to use advanced risk analysis tools in the decision-making process. This presentation discusses a general formulation for regional risk and resilience analysis. The presentation explains how to conduct a regional risk and resilience analysis considering multiple hazards and different infrastructure, as well as the effects of deterioration and interdependencies among infrastructure. Finally, the presentation concludes with the modeling of business interruption due to a hypothetical earthquake in the New Madrid seismic zone.